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Mean concentration time profiles and all the pharmacokinetic parameters of rifampicin, isoniazid and pyrazinamide from fdc tablet were comparable to individual formulations and passed the bioequivalence test with power of the test above 95 .

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probably not treatment of latent tuberculosis infection with 9-12 months of daily isoniazid assuming excellent adherence is 80-90 effective in eliminating the latent infection.

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isoniazid is an inhibitor of the hepatic isoenzyme cyp3a4; boceprevir is metabolized by this isoenzyme.

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rifampin is an acceptable alternative for those patients who cannot tolerate isoniazid.


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