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to strengthen our hypothesis that the anti-inflammatory effects of metformin were mediated by activation of ampk, we used another activator of ampk, 5-aminoimidazole-4-carboxamide ribonucleoside aicar , which has been shown previously to be anti-inflammatory 28 .

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glipizide and metformin is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes.

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5 , its approval was undoubtedly delayed by the specter of phenformin and the lingering concern that metformin might also cause lactic acidosis.

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